Impact Colostrum - www.wombaroo.com.au

Colostrum is the first milk produced after birth, containing high levels of immunoglobulins and antibacterials, that provide immunity and intestinal protection to young animals.

Impact Colostrum Supplement is made from powdered bovine colostrum with added whey protein, lactalbumin, omega-3 and omega-6 fatty acids, vitamins and minerals.

Feed Impact to newborn animals or marsupial joeys as a replacement for or as an adjunct to milk replacers.

Body Weight (g)	Impact Heaped spoons	Warm Water (ml)	Daily Impact Dose (ml)	Body Weight (kg)	Impact Powder (g)	Warm Water (ml)	Daily Impact Dose (ml)
up to 50	^1/2	2	2	1 to 2	15	48	60
50 to 100	1	3	4	2 to 3	20	64	80
100 to 200	2	8	10	3 to 4	25	80	100
200 to 300	3	13	16	4 to 5	30	96	120
300 to 400	4	16	20	5 to 10	60	190	240
400 to 500	5	20	24	10 to 20	100	320	400
700 to 800	6	24	30	20 to 30	130	420	520
800 to 900	7	30	36	30 to 40	160	510	640
900 to 1000	8	32	40	40 to 50	200	640	80

This applies to all domestic animals including cats, dogs, rabbits, rats, guinea pigs, horses, alpacas, cows, sheep, pigs & deer. Also used for eutherian wildlife and zoo mammals.

Impact should be fed as soon as possible after birth, and preferably before milk is fed. Impact can be absorbed for upto 48 hours after birth, depending on the species. Weigh the animal and select the appropriate weight range from the chart. Mix the amounts of Impact powder and warm pre-boiled water to make the daily Impact requirement. Refrigerate prepared Impact for one day only or store frozen in ice cube trays for up to 1 month.

First 12 hours: Do not feed milk during this time. Prepare a daily dose of Impact as described above and feed ¹/₄ of the amount every 2 hours.

Next 36 hours: Commence feeding milk every 4 hours. Prepare a daily dose of Impact as described above and feed ¹/₄ of the amount every 4 hours. Feed Impact 2 hours after the first milk feed so that the remaining Impact feeds are mid way between the next milk feeds.

First 12 hours: Stop feeding milk. Prepare a daily dose of Impact as described above and feed ¹/₄ of the amount every 2 hours.

Next 36 hours: Recommence feeding milk. Prepare a daily dose of Impact as described above and feed ¹/₄ of the amount mid way between milk feeds.

Marsupials are different in that they do not produce a colostral milk. Impact is added to marsupial milk because intestinal closure occurs later in marsupiaIs and immunoglobulins are present in milk for much of lactation.

For very early lactation to mid lactation (Wombaroo <0.4 to 0.6): Select the appropriate amount of Impact powder for body weight from the chart. Mix the powder into the required daily volume of milk and feed as usual. This procedure may be repeated for up to 5 days.

For late lactation (Wombaroo >0.7): Select the appropriate amount of Impact for body weight from the chart and add this to the normal daily feed volume of milk. Repeat if required.

Colostrum is the first milk produced after birth. It is high in protein much of which is immunoglobulin. Immunoglobulins are a group of proteins with antibody activity that are produced in response to infection by micro-organisms. The three main classes of immunoglobulins are Immunoglobulin A (IgA), Immunoglobulin G (IgG) and Immunoglobulin M (IgM). A few mammals such as rabbits, mice and humans are born with maternal transplacental IgG but not IgA or IgM. However most species are born devoid of immunity and must acquire their initial immunoglobulins from colostrum. For the immunoglobulins in colostrum to function as systemic antibodies they must first be absorbed from the intestine unaltered ^1,2,9. Colostrum contains other proteins such as, lactoferrin, lactoperoxidase and lysozyme that have antibacterial activity. These proteins act to inhibit the colonisation of the intestine by pathogenic micro-organisms^4,10 and together with low levels of immunoglobulins may remain in the milk throughout lactation. These proteins are usually found in higher concentrations in colostrum and early lactation milk ^3,8.

Lactoferrin binds iron and facilitates its uptake from the intestine. Due to its iron binding capacity lactoferrin inhibits a wide range of micro-organisms that require iron for growth^5,7. When lactoferrin is hydrolysed by gastric enzymes it releases a peptide that is highly bactericidal to several species of pathogenic organisms ¹².

Lactoperoxidase is bacteriostatic to a wide range of bacteria in the presence of thiocyanate and hydrogen peroxide generating enzymes ^4,5,11. Lactoperoxidase denatures bacterial proteins by halogenation with hydrogen peroxide and halogens.

Lysozyme is bactericidal to many bacteria. Lysozyme hydrolyses the muramic acid in the cell wall thus causing the bacterial cell to lyse. Lysozyme also acts in concert with IgA, lactoperoxidase and ascorbate to lyse bacteria.

In eutherians, colostral milk is only produced for a short time after birth. During this time ingested antibodies are protected from intestinal digestive enzymes by antiproteinases present in the colostrum. Intestinal closure to the absorption of antibodies occurs as the composition of mammary secretion changes from colostrum to normal milk, when the levels of antibody fall rapidly ^2,9.

In marsupials, there is probably no colostrum as such. Intestinal closure occurs later in pouch life so antibodies are present in the milk throughout much of lactation ^6,13.

References

1. Barth, C.A. & E Schimmel. 1988. In “Milk Proteins.” Pp 72-111. Eds. C.A. Barth & E Schimmel.

3. Elliot, J.I., B. Senft, G. Erhardt & D. Fraser. 1984. J. Anim. Sci., 59: 1080-1084.

5. IDF Bulletin 191. 1985. Protective proteins in milk: Biological significance and exploitation.

7. Kawakami, H., M. Hiratsuka and S. Dosaka. 1988. Agric. Biol. Chem., 52: 903-908.

9. In “Milk: the mammary gland and its secretion”. Eds. S.K. Kon & A.T. Cowie. Academic Press.

11. Reiter, B. 1978. Antimicrobial systems in milk. J. Dairy. Res., 45: 131-147.

Total Protein	635g	Lactose	100g
Total Fat	68g	Total Immunoglobulin	74g
Total Carbohydrate	280g	Lactoferrin	6g
ME	17.2MJ	Lactoperoxidase	300000U